NEWS

Professor Dr. Andras Dinnyes (the owner and general director of BioTalentum Ltd.) was giving a lecture at M1 (Hungarian TV cannel) on Wednesday night. He talked about cloning and genetechnology.


You can view the interview at the following link: www.mediaklikk.hu/video/ma-este-2016-01-27-i-adas/
 

10 years in Biotechnology
August 13th, 2015

BioTalentum 10th Anniversary Scientific Workshop Series is organised for 29th September in Budapest, Hungary.

Biotalentum Kft. és Consulting Üzletág - Innotéka cikk

 

Our company was introduced in the following artice published by Napi Gazdaság Online:

READ THE HUNGARIAN ARTICLE

Dr. Andras Dinnyes was the last invited speaker of the series "Everyday Science" organised by Pannon University on 9th April 2014 at Keszthely, Hungary.

 

Our NAD project won the Second prize award in the section “Best Completed Project Contest” during the award ceremony that took place at Conference Dinner of Industrial Technologies 2014 Conference 2014 on April 10th, 2014.

 

The prize was been given to the project coordinator Prof. Massimo Masserini by Clara de la Torre, Director responsible for "Research and Innovation" in the European Commission.

 

 

 

 

Dr. Andras Dinnyes presented the Marie Sklodowska-Curie Actions - H2020 (EU) on the workshop "Advancing Your Research Cereer in Europe - Funding and Fellowship Opportunities for Southeast Asian Researchers" on 22nd January in Bangkok, Thailand and 24th January 2014 at One-North, Singapore.

Hungarian Talent Market
January 23rd, 2014

BioTalentum is involved into the activities of the Hungarian Association of Talent Support Organisations. Details of the activities can be read on the following website:

tehetseg.hu/en

 

The opening event of the Hungarian Talent Market Program was organised Last Saturday (18th January). The main object of this program is a mentoring project for young talents, where the mentors will help selected young talents with their scientific and personal experiences. We were participated on this event:

 

 

 

Please find attached the photos of the event last Saturday and the link of the Hungarian article:
tehetseg.hu/aktualis/magas-volt-az-egy-negyzetmeterre-juto-nagy-talalkozasok-szama
 

Dr. András Dinnyés is one of the ten researchers receiving the Dénes Gábor Award in 2013. The prize is awarded by the NOVOFER Foundation.

 

 

Video about the event: LINK

New Article
October 15th, 2013

Our new open access article has been published online:

Hadas Raveh-Amit, Sara Berzsenyi, Virag Vas, Danna Ye and Andras Dinnyes: Tissue resident stem cells: till death do us part. Biogerontology

Available as 'Online First' on SpringerLink

Utrecht University, Szent Istvan University Godollo, and BioTalentum Ltd. have the pleasure of inviting you to the Open Workshop of the StemCam and EpiHealthNet FP7 projects, on the 25th of November, 2013. at Gödöllő, Hungary. As there are 50 places to fill, please be aware, that the event is going to be held on the “first come – first served” basis. Please, register at Krisztina.Otyehel@biotalentum.hu . The event is free of charge for the registered participants.

 

HORIZON2020 Launch event special: BioTalentum Consulting free offer during the workshop:
- Horizon2020 information desk
- Free 20 minutes consultancy service about the new calls of Horizon2020!
Please register for time slot at consultancy@biotalentum.hu
 


AGENDA
25th November 2013 9:00-14:00
Epigenetic and molecular influences on early development and stem cell differentiation


VENUE: Erzsébet királyné Hotel, Gödöllő, Dózsa György út 2.

8:15- Registration
9:00-9:10 Welcome by Prof. Andras Dinnyes: The Epihealthnet and Stemcam FP7 projects, advices to Horizon2020.

9:10-9:40 Prof. Andras Dinnyes (Utrecht University, The Netherlands, Biotalentum Ltd, Hungary): Overview of recent highlights of the pluripotent stem cell field.

9:40-10:10 Prof. Tom P. Fleming (University of Southampton, UK): Embryo-environment interactions and their legacy into adulthood

10:10-10:40 Prof. Sue Kimber (University of Manchester, UK): Human Embryonic stem cells

10:40-11:00 Coffee break

11:00-11:30 Dr. Sára Berzsenyi (BioTalentum Ltd. Hungary): Neuronal differentiation of pluripotent stem cells

11:30-12:00 Dr. Pawan Singh, Dr. Alexandra Blak (STEMCELL Technologies, Canada): Complete and Defined Feeder-free Maintenance and Reprogramming Systems to Support Human Pluripotent Stem Cell Research

12:00-12:30 Lone Neelchen Roesingh (University of Geneva, Switzerland): The effect of γ-secretase inhibitors on differentiation of stem cells

12:30-13:00 Christoph Schaefer (UKK, Germany): Cardiac toxicity: in vitro functional readout approach

13:00- 14:00 Sandwich Lunch – at Erzsébet királyné Hotel
 

 

Pro Sceincia Golden Medalists

Organiser: Pro Scientia Aranyérmesek Társasága

Date: May 3, 2013, 16:00-17:30
Speaker: Dr. Dinnyés András
School: Károli Gáspár Református Egyetem, Díszterem Budapest 1088 Reviczky utca 4.
Hungarian Lecture: Bőrből idegsejtek létrehozása, avagy a genetikai újraprogramozás csodálatos új világa

Registration: http://www.psat.hu/

Hungarian summary: http://www.psat.hu/alom/alomdinnyes.html?dl=1

Full video: http://www.youtube.com/watch?v=M1NfuDo-k5s&feature=youtu.be

 

Meet the scientist - Meeting
March 11th, 2013

Date: February 20, 2013, 14:00
Speaker: András Dinnyés
School: ELTE Radnóti Miklós High School, Budapest
Lecture: Clones and Stem Cells - the mystery of the genetic reprogramming

Video: www.youtube.com/watch

Web: www.meetthescientist.hu/index_en.php

We warmly invite you to be a part of the NANOPARTICLES IN MEDICINE 2013 International conference, one of the largest annual international scientific conference devoted to Medical application (design, toxicology, use in diagnosys / therapy) aspects of the Nanoparticles.

The conference is organised as part of the final meeting of the NAD (Nanoparticles for therapy and diagnosis of Alzheimer's disease) Project which is aiming to develop nanoparticles for Alzheimer's diagnosis and therapy. The research of NAD is financed by the European Union's 7th Framework Program and includes 19 European research centers. Grant agreement no: CP-IP 212043-2 NAD.

The conference will be held in Milan, Italy.

FREE OF CHARGE. Registration: http://www.npmed13.eu/
 

BioTalentum Ltd. has the pleasure of inviting you to the 4th Yearly Open Workshop of the InduStem ‘Comparative stem cell research in mouse and humans’ FP7 project, coordinated by the company, on the 23rd of November, 2012. at Gödöllő, Hungary. As there are 50 places to fill, please be aware, that the event is going to be held on the “first come – first served” basis. Please, register at nora.burgmann@biotalentum.hu. The event is free of charge for the registered participants.


AGENDA
23rd November 2012 9:00-13:30
Models of pluripotent stem cell differentiation in animals and humans


VENUE: Erzsébet királyné Hotel, Gödöllő, Dózsa György út 2.


8:15- Registration
9:00-9:10 Welcome by Prof. Andras Dinnyes
9:10-9:40 Prof. Andras Dinnyes (Biotalentum Ltd, Hungary) Induced pluripotent stem cells: from discovery to Nobel price, and beyond
9:40-10:10 Prof. Daniel Brison (University of Manchester, UK) Transcriptome analysis of human embryos and embryonic stem cells: towards EpiHealth
10:10-10:40 Prof. Christine Mummery (Leiden University Medical Center, NL) Human pluripotent stem cells: the new patient
10:40-11:10 Prof. Kent Thornburg (Oregon Health & Science University, Portland, USA) The regulation of cardiomyocyte replication in the fetal heart
11:10-11:30 Coffee break
11:30-12:00 Prof. Zoltan Ivics (Max Delbrück Center for Molecular Medicine/ Paul Erlich Institut, Germany) Sleeping Beauty Transposon-based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells
12:00-12:30 Dr. Yutao Du (Beijing Genomic Institute, BGI). The contribution of NGS for stem cell research
12:30-13:00 Dr. Virág Vas (Szent Istvan University, Hungary) The cancer stem cells theory in the view of genetic reprogramming
13:00-13:30 Prof. Antal Nógrádi (University of Szeged, Hungary) Rescue of spinal motoneurons destined to die by grafted iPS cells: what can we learn from stem cells?
13:30- 15:00 Lunch – at Erzsébet királyné Hotel

BioTalentum Ltd. has the pleasure of inviting you to the Yearly Open Workshop of the PartnErS ‘Comparative embryonic stem cell research in mammalians’ FP7 project, coordinated by the company, on the 25th. of September, 2012. to Budapest, Hungary. As there are 120 places to fill, please be aware, that the event is going to be held on the “first come – first served” basis. Please, register at nora.burgmann@biotalentum.hu. The event is free of charge for the registered persons.

 

Agenda

 

VENUE: Hotel Gellert, Budapest, 1111 Budapest Szent Gellért tér 1


8:30- Registration
8:50- 8:55 Welcome speech by Prof. Andras Dinnyes, Biotalentum Ltd., Gödöllő, Hungary
8:55-9:15 Perspectives of Stem Cell Based Applications in Medicine and Pharma Industry/ Prof. Andras Dinnyes, BioTalentum Ltd, Hungary
9:15- 9:40 Pluripotent stem cells for cell therapy: challenges in expansion and safety/ Dr. Andre Choo, National University of Singapore, Singapore
9:40-10:05 Specialized media and reagents for tissues specific cells and derivatives of human pluripotent stem cells/ Dr. Sharon Louis, STEMCELL Technologies Inc., Canada
10:05-10:30 The role of FGF signaling in the formation of the epiblast / Dr. Bernard Roelen, Universiteit Utrecht, Netherlands
10:30-10:55 Coffee break
10:55-11:20 Human and porcine pluripotent stem cells and neural differentiation
Prof. Poul Hyttel/ University Of Copenhagen, Denmark
11:20-11:45 Transgene-free human induced pluripotent stem cells from umbilical cord blood-derived cells: milestone for clinical applications / Dr. Ruttachuk Rungsiwiwut, Chulalongkorn University, Thailand
11:45-12:10 Application of neural stem cells in brain diseases: what happens after transplantation? / Dr. Dinko Mitrecic, Croation Brain Council
12:10-12:35 Drug discovery using pluripotent stem cell derived systems/Dr. Sara Berzsenyi, BioTalentum, Hungary
12:35- 13:00 Identification of neuroactive and neurotoxic substances using pluripotent stem cell based assays/Prof. Karl-Heinz Krause, University of Geneva, Switzerland
13:00-15:00 Networking event: lunch

InduStem Workshop III.
September 20th, 2011

We would like to invite you to the
3rd Yearly Open Workshop of INDSUTEM FP7 project, coordinated by BioTalentum Ltd
Stem Cell modifications: transposon and other transgenic technologies and epigenetic changes
22nd November 2011 9:00-15:00
Godollo, Hungary
Szent Györgyi Albert u 4. Agricultural Biotechnology Center Godollo, Hungary


8:30-9:00    Registration


9:00-9:10    Opening by Prof. Andras Dinnyes (BioTalentum Ltd and Agricultural Biotechnology Center, Gödöllő, Hungary)


9:10-9:40   Prof. Roger A. Pedersen (University of Cambridge, UK)
Mechanisms of mesoderm differentiation in pluripotent mammalian stem cells


9:40-10:10    Prof. Tom Fleming (University of Southampton, UK)
Lecture on Environmental effects on early development and adult health


10:10-10:40    Prof. Helen Byrne (University of Nottingham, UK)
The role of wnt signalling in the intestinal crypt - a theoretical investigation


10:40-11:00    Coffee break

11:00-11:30    Prof. Carlos Malpica (MLP Vision Biotech S.L, Spain and Metabolon Inc, USA)
Metabolomic analyses of biological samples


11:30-12:00    Dr. Olga Ujhelly (BioTalentum Ltd) 
Improved gene transfer system to iPS cells in mouse


12:00-12:30    Prof. Zoltan Ivics (Max Delbrück Center, Berlin, Germany)
Genetic engineering with Sleeping Beauty transposons


12:30-13:00    Dr. Richard Davis (Leiden University Medical Center, The Netherlands)
Pluripotent stem cell models of a human cardiac sodium ion channelopathy


13:00-13:30    Prof. Christine Mummery (Leiden University Medical Center, The Netherlands)
Pluripotent stem cells in cardiovascular disease and drug safety pharmacology


13:30- 15:00     Buffet Lunch/End of the workshop

Background

 

The POU5F1 gene encodes the octamer-binding transcription factor-4 (Oct4). It is crucial in the regulation of pluripotency during embryonic development and widely used as molecular marker of embryonic stem cells (ESCs). The objective of this study was to identify and to analyse the promoter region of rabbit POU5F1 gene; furthermore to examine its expression pattern in preimplantation stage rabbit embryos.

 

Results

 

The upstream region of rabbit POU5F1 was subcloned sequenced and four highly conserved promoter regions (CR1-4) were identified. The highest degree of similarity on sequence level was found among the conserved domains between rabbit and human. Among the enhancers the proximal enhancer region (PE-1A) exhibited the highest degree of homology (96.4%). Furthermore, the CR4 regulator domain containing the distal enhancer (DE-2A) was responsible for stem cell-specific expression. Also, BAC library screen revealed the existence of a processed pseudogene of rabbit POU5F1. The results of quantitative real-time PCR experiments showed that POU5F1 mRNA was abundantly present in oocytes and zygotes, but it was gradually reduced until the activation of the embryonic genome, thereafter a continuous increase in POU5F1 mRNA level was observed until blastocyst stage. By using the XYClone laser system the inner cell mass (ICM) and trophoblast portions of embryos were microdissected and examined separately and POU5F1 mRNA was detected in both cell types.

 

Conclusion

 

In this study we provide a comparative sequence analysis of the regulatory region of rabbit POU5F1 gene. Our data suggest that the POU5F1 gene is strictly regulated during early mammalian development. We proposed that the well conserved CR4 region containing the DE-2A enhancer is responsible for the highly conserved ESC specific gene expression. Notably, we are the first to report that the rabbit POU5F1 is not restricted to ICM cells only, but it is expressed in trophoblast cells as well. This information may be well applicable to investigate further the possible phylogenetic role and the regulation of POU5F1 gene.

 

OPEN ACCESS 

Scientific Week
August 31st, 2009

September Training and conference week


On the 21-25. September, 2009. BioTalentum ltd organize a Scientific Week, connected to its several FP6 and 7 projects. Duirng the event are great authorities will persent about embrionic stem cells and induced pluripotent stem cells.

 

AGENDA


21. September

8:00-12:00 MedRat Final Meeting
14:00-16:00 Clonet Annual Meeting


22.September
9:00-13:00: PartnErS project yearly opened workshop

 

Title: Nuclear transfer and embryonic stem cell research in animal models

 

Invited speakers:

 

9:00-9:30 Prof. András Dinnyés:
“EU funded research for nuclear transfer and embryonic stem cell research in animal models”
9:30-10:00 Prof. Poul Hyttel:
“Stem cells and genetic modifications in the pig - a refined biomedical model”
10:00-10:30 Dr. Ruttachuk Rungsiwiwut:
“Differentiation of human embryonic stem cells into neural lineage “
10:30-11:00 Coffee break
11:00-11:30 Prof. Keith Cambell:
“Recloning Dolly: Improving efficiencies of ovine SCNT through manipulation of oocyte kinase activities”
11.30-12:00 Prof. Johannes Beckers:
“How is your genome today? - Expression profiling and phenotyping of cloned mice”
12:00-12:30 Prof. Roger A. Pedersen:
“Mechanisms of pluripotency and differentiation in mammalian embryonic stem cells”
12:30-13.00 Poster presentation
13:00 LUNCH – at Queen Elizabeth Hotel

 

15:00-18:00
Training session for project partners

 

Linking Science to Business
Ernő Duda- Solvo Biotechnology
Prof. András Dinnyés
Spining off in New Member States
Előadó:Sulev Koks
Prof. András Dinnyés
IP management /IP management and tech transfer
Dr. Katalin Mikló

 

23.September
9:00-13:00 InduStem yearly opened workshop
Title: Generation of iPS cells by various transgenic methods

 

9:00-9:35 Dr. Christian Freund:
“Generation of iPS cell lines from human patient material”
9:35-10:10 Dr. Richard Davis:
“Mouse pluripotent stem cell models of a human cardiac sodium channelopathy”
10:10-10:45 Dr. Olga Ujhelly:
“Establishment and characterization of mouse induced pluripotent stem cells”
10:45-11:20 Coffee break
11:20-11:55 Prof. Zoltán Ivics:
“Transposable elements as nonviral gene vectors”
11:55-12:30 Prof. Bruce Whitelaw:
“Ovine iPS cells”
12:30-13.00 Poster presentation
13:00 LUNCH – at Queen Elizabeth Hotel

 

15:00-18:00
Training section for project partners

 

1) EU project writing, contracting and management
Ágnes Gulyás, NKTH
2) Management of multicultural research teams
Prof. András Dinnyés

 

Szeptember 24-25:
Real Time training for the CLONET team 

The conference and exhibition took place in Prague from 7 to 8 May 2009. Prof. András Dinnyes was an invited speaker in Marie Curie Session. Webcast of the presentations can be seen HERE and HERE.
My Science project exhibited in the conference.

OTDK triumph
April 21st, 2009